Related Products of 37622-90-5, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 37622-90-5, Name is Ethyl 4-pyrazolecarboxylate, SMILES is C1=N[NH]C=C1C(OCC)=O, belongs to pyrazoles-derivatives compound. In a article, author is Nazarov, Mikhail A., introduce new discover of the category.
Synthesis of 1,2-azole derivatives on the basis of alpha,beta-unsaturated triterpene aldehydes
alpha,beta-Unsaturated lupane and 19 beta,28-epoxy-18 alpha-oleanane aldehydes were used in the synthesis of triterpenoids bearing substituted 1,2-azole moieties (1-acetyl-3-methyl-4,5-dihydro-1H-pyrazole and 3-methyl-4,5-dihydroisoxazole) at the rings A and E. The route of synthesis for these 1,2-azole derivatives of triterpenes included an aldol condensation of alpha,beta-unsaturated aldehydes with acetone, the products of which (alpha,beta-unsaturated methyl ketone and beta-hydroxy ketone) underwent a further cycloaddition reaction with acetylhydrazide and hydroxylamine. Cytotoxic activity studies of the synthesized compounds against seven cancer cell lines (Hep-2, HCT116, MS, RD TE32, A549, MCF-7, and PC-3) showed that the highest cytotoxicity (IC50 0.66-11.97 mu M) against all tested cell lines was exihbited by 19 beta,28-epoxy-18 alpha-oleanane aldehyde and the products of its condensation reactions with acetone and acetylhydrazide.
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Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics