The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. Category: pyrazoles-derivatives, 35344-95-7, Name is 1H-Pyrazole-4-carbaldehyde, SMILES is O=CC1=CNN=C1, in an article , author is Zhang, Maoyuan, once mentioned of 35344-95-7.
Cu(I)-N-heterocyclic carbene-catalyzed base free C-N bond formation of arylboronic acids with amines and azoles
A new N-heterocyclic carbene (NHC) precursor of imidazolium chloride and its corresponding Cu(I)-NHC complex 1 was synthesized. The complex 1 was found to be a highly effective catalyst for Chan-Evans-Lam coupling of arylboronic acid with amines and azoles (including imidazole, pyrazole and triazole), without addition of base at room temperature. Various substituents on three substrates can be tolerated, giving the desired coupling products in good to excellent yields (62-94%). The method is practical and offers an alternative to the corresponding copper-catalyzed Chan-Evans-Lam process for the construction of C-N bonds. (C) 2020 Published by Elsevier Ltd.
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Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics