Chemistry, like all the natural sciences, begins with the direct observation of nature¡ª in this case, of matter.37622-90-5, Name is Ethyl 4-pyrazolecarboxylate, SMILES is C1=N[NH]C=C1C(OCC)=O, belongs to pyrazoles-derivatives compound. In a document, author is Reddy, Chitreddy V. Subba, introduce the new discover, Name: Ethyl 4-pyrazolecarboxylate.
l-Proline Catalyzed Synthesis of Highly Functionalized 4-Hydroxy-4H-chromene-pyrazoles and 4-Hydroxy-4H-chromene-barbiturates in Aqueous Medium
A simple and efficient method for the synthesis of novel 4-hydroxy-4H-chromene-pyrazoles and 4-hydroxy-4H-chromene-barbiturates was developed from the reaction of 2-ethoxy-2H-chromene chalcones with pyrazolin-5-one and barbituric acid catalyzed byl-proline in water. The developed protocol is applicable for the construction of biologically important 4H-chromenes from easily accessible chalcones having various substituents. This reaction proceeds through Aldol condensation, Michael addition and hydrolysis reactions followed by the elimination of ethoxy group. This methodology offers cleaner conversion, a shorter reaction time and high yields. For the first time, we report the synthesis of novel 4-hydroxy-4H-chromenes from 2-ethoxy-2H-chromene chalcones and pyrazolin-5-one/barbituric acid usingl-proline(72-86 %yield in 6 h). Water was used as the solvent for all the compounds it represents a green synthetic protocol.
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 37622-90-5 is helpful to your research. Name: Ethyl 4-pyrazolecarboxylate.
Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics