In an article, author is Metwally, Nadia Hanafy, once mentioned the application of 37622-90-5, Computed Properties of C6H8N2O2, Name is Ethyl 4-pyrazolecarboxylate, molecular formula is C6H8N2O2, molecular weight is 140.14, MDL number is MFCD00010844, category is pyrazoles-derivatives. Now introduce a scientific discovery about this category.
Synthesis, reactions, and antimicrobial activity of2-cyano-N ‘-(4-(2-oxo-2-phenylethoxy)benzylidene)acetohydrazide derivatives
Knovenagel condensation of the starting 2-cyano-N ‘-(4-(2-oxo-2-phenylethoxy)-benzylidene)acetohydrazide with different aromatic aldehydes produced the comparable arylidenes derivatives. Else way, 2-cyano-N ‘-(4-(2-oxo-2-phenylethoxy)-benzylidene)-acetohydrazide condensed witho-hydroxybenzaldehydes affording the respective chromenes which latter underwent acid hydrolysis giving the oxo-chromenes analogues. Moreover, the reaction of 2-cyano-N ‘-(4-(2-oxo-2-phenylethoxy)benzylidene)acetohydrazide with istain yielded the respective indeno[2,1-b]furan derivative that was converted to its oxo-analogue through acid hydrolysis. The treatment of 2-cyano-N ‘-(4-(2-oxo-2-phenylethoxy)benzylidene)acetohydrazide with alpha-halocompounds produced the relevant thiazoles. The enamine 2-cyano-3-(dimethylamino)-N ‘-(4-(2-oxo-2-phenylethoxy)benzylidene)acrylohydrazide underwent nucleophilic substitution reaction with guanidine hydrochloride followed by heterocyclization to get the relative aminopyrimidine. Contrarily, the reaction with various 4-arylazo-3,5-diaminopyrazoles provided the relative pyrazolo[1,5-a]pyrimidines. The antimicrobial investigation was carried out for some of the newly synthesized compounds using agar well diffusion method.
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Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics