Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 67-51-6, Name is 3,5-Dimethyl-1H-pyrazole, molecular formula is C5H8N2. In an article, author is Huang, Hao,once mentioned of 67-51-6, Application In Synthesis of 3,5-Dimethyl-1H-pyrazole.
Discovery of novel benzofuran scaffold as 4-hydroxyphenylpyruvate dioxygenase inhibitors
BACKGROUND 4-Hydroxyphenylpyruvate dioxygenase (HPPD) plays an important role in addressing the issue of plant protection research. This study sheds new light on the differences in molecular scaffold from commercialized HPPD inhibitors. RESULTS The compounds A1-A18 and B1-B27 were synthesized for in vitro and greenhouse experiments. The greenhouse experiment data indicated that compounds B14 and B18 displayed excellent herbicidal activity, which was higher compared to that of mesotrione. In vitro testing indicated that the compounds were HPPD inhibitors. Moreover, molecular simulation results show that the compounds B14, B18, and mesotrione shared similar interplay with surrounding residues, which led to a perfect interaction with the active site of Arabidopsis thaliana HPPD. Based on crop selectivity results, compounds B14 and B18 were selected for maize studies (injury <= 10%), indicating its potential for weed control in maize fields. CONCLUSION These results showed that the pyrazole-benzofuran structure could be used as possible lead compounds for the development of HPPD inhibitors. If you¡¯re interested in learning more about 67-51-6. The above is the message from the blog manager. Application In Synthesis of 3,5-Dimethyl-1H-pyrazole.
Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics