Related Products of 50-33-9, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 50-33-9, Name is Phenylbutazone, SMILES is O=C(C1CCCC)N(C2=CC=CC=C2)N(C3=CC=CC=C3)C1=O, belongs to pyrazoles-derivatives compound. In a article, author is Li, Weisong, introduce new discover of the category.
17 beta-Estradiol Protects Neural Stem/Progenitor Cells Against Ketamine-Induced Injury Through Estrogen Receptor beta Pathway
Ketamine inhibits neural stem/progenitor cell (NSPC) proliferation and disrupts normal neurogenesis in the developing brain. 17 beta-Estradiol alleviates neurogenesis damage and enhances behavioral performance after ketamine administration. However, the receptor pathway of 17 beta-estradiol that protects NSPCs from ketamine-induced injury remains unknown. In the present study, we investigated the role of estrogen receptor alpha (ER-alpha) and estrogen receptor beta (ER-beta) in 17 beta-estradiol’s protection against ketamine-exposed NSPCs and explored its potential mechanism. The primary cultured NSPCs were identified by immunofluorescence and then treated with ketamine and varying doses of ER-alpha agonist 4,4 ‘,4 ”-(4-propyl-[1H]-pyrazole-1,3,5-triyl) trisphenol (PPT) or ER-beta agonist 2,3-bis(4-hydroxyphenyl)-propionitrile (DPN) for 24 h. NSPC proliferation was analyzed by 5-bromo-2-deoxyuridine incorporation test. The expression of phosphorylated glycogen synthase kinase-3 beta (p-GSK-3 beta) was quantified by western blotting. It was found that treatment with different concentrations of PPT did not alter the inhibition of ketamine on NSPC proliferation. However, treatment with DPN attenuated the inhibition of ketamine on NSPC proliferation at 24 h after their exposure (P< 0.05). Furthermore, treatment with DPN increased p-GSK-3 beta expression in NSPCs exposed to ketamine. These findings indicated that ER-beta mediates probably the protective effects of 17 beta-estradiol on ketamine-damaged NSPC proliferation and GSK-3 beta is involved in this process Related Products of 50-33-9, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 50-33-9.
Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics