These common heterocyclic compound, 120068-79-3, name is 5-Amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-1H-pyrazole-3-carbonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C11H5Cl2F3N4
EXAMPLE 3 Preparation of 5-Amino-1-(2,6-dichloro-4-trifluoromethylphenyl)-3-cyanopyrazol-4-yl disulphide Acetonitrile (837 g) was added to a chlorobenzene solution (627.8 g) which contained 5-amino-1-(2,6-dichloro-4-trifluoromethylphenyl)-3-cyanopyrazole (366.6 g, 1.14 mol). The mixture was heated at 50-64 C. under reduced pressure (0.5 atmosphere) and dried by the distillation of about 45 ml of the acetonitrile. After cooling to 18 C., sulphur monochloride (77 g, 0.57 mol) was added rapidly over 1 minute. The temperature of the mixture increased to 35 C. and was maintained at 35 C. by cooling until the exotherm ceased and for a further 0.3 hour. The mixture was then degassed (to remove hydrogen chloride) by heating at 40 C. under reduced pressure, and then heated at 80 C. for 1 hour at atmospheric pressure. After cooling to 30 C., ammonia was added to bring the pH to 6.5-7, cooled to 5 C. and the product filtered off, washed with chlorobenzene/acetonitrile and dried at 95 C. under vacuum to give the title compound (365.2 g) in typical yield of 89.4% and 98.4% purity.
The synthetic route of 5-Amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-1H-pyrazole-3-carbonitrile has been constantly updated, and we look forward to future research findings.