Related Products of 52222-73-8, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 52222-73-8, name is 4-(Trifluoromethyl)-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows.
3-(3-(4-(chloromethyl)benzyl)isoxazol-5-yl)pyridin-2 -amine (Intermediate B, 80mg, 0.27mmol) and 4-(trifluoromethyl)-lH-pyrazole (l45mg, l .07mmol) were dissolved in NMP (lml). Potassium 2- methylpropane-2-olate (1M in THF, 0.80mL, 0.80mmol) was added and the mixture was stirred for 5min at 60C. The cooled reaction mixture was directly purified by column chromatography (Si02, hexane/ethyl acetate). Fraction containing the product were concentrated under reduced pressure and further purified by HPLC to yield 3-(3-(4-((4-(trifluoromethyl)-lH-pyrazol-l-yl)methyl)benzyl)isoxazol- 5-yl)pyridin-2-amine (75mg, 0. l9mmol, 70%) as a white solid. 400 MHz ‘H NMR (CDC13) d 8.14 (d, ./ = 3.7 Hz, 1H), 7.73 (s, 1H), 7.69 (dd, J= 7.7, 1.8 Hz, 1H), 7.64 (s, 1H), 7.30 (d, J= 8.2 Hz, 2H), 7.22 (d, J = 8.2 Hz, 2H), 6.70 (dd, J= 7.7, 4.9 Hz, 1H), 6.25 (s, 1H), 5.43 (s, 2H), 5.29 (s, 2H), 4.05 (s, 2H). MS: 400.3 [M+H]+.
The chemical industry reduces the impact on the environment during synthesis 4-(Trifluoromethyl)-1H-pyrazole. I believe this compound will play a more active role in future production and life.