A new synthetic route of 151521-49-2

According to the analysis of related databases, 151521-49-2, the application of this compound in the production field has become more and more popular.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 151521-49-2, name is 4-Isopropyl-1H-pyrazol-5-amine, This compound has unique chemical properties. The synthetic route is as follows., name: 4-Isopropyl-1H-pyrazol-5-amine

A mixture of methyl 3-(5-bromo-3-pyridyl)-3-oxo-propanoate (300 mg, 813.74 mupiiotaomicron, 1 eq) and 4-isopropyl-lH-pyrazol-5-amine (122.23 mg, 976.49 mupiiotaomicron, 1.2 eq) in AcOH (10 mL) was stirred at 120 C for 0.5 h. The mixture was concentrated under reduced pressure to give 5-(5-bromo-3- pyridyl)-3-isopropyl-pyrazolo[l,5-a]pyrimidin-7-ol (450 mg, crude) as brown oil which was used in next step without further purification. NMR (400 MHz, CDCl3) S ppm 8.99-8.88 (m, 1H), 8.74-8.73 (m, 1H), 8.39-8.37 (m, 2H), 7.79 (s, 1H), 3.21-3.20 (m, 1H), 1.39-1.33 (m, 6H); ES- LCMS m/z 333.0, 335.0 [M+H].

According to the analysis of related databases, 151521-49-2, the application of this compound in the production field has become more and more popular.