Related Products of 285984-25-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 285984-25-0, name is 3-(tert-Butyl)-1-(p-tolyl)-1H-pyrazol-5-amine belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
To a solution of CDI (91 mg, 0.56 mmol) in DCM (1.0 mL) was added Intermediate A1 (129 mg, 0.563 mmol) and the reaction mixture maintained at RT for 2 hr. A portion of this solution (500 pL, 0.28 mmol) was added to a solution of Intermediate B16 (80 mg, 0.19 mmol) in THF (2.0 mL) and the reaction mixture kept at RT for 3 hr and then quenched with the addition of MeOH (2.0 mL). The resulting mixture was evaporated in vacuo and the residue was purified by flash column chromatography (Si02, 12 g, 0-100% [10% MeOH in EtOAc] in isohexane, gradient elution) to afford methyl 5-((4-((4-(3-(3-(ierf-butyl)-1-(p-tolyl)-1 H-pyrazol- 5-yl)ureido)naphthalen-1-yl)oxy)pyrimidin-2-yl)amino)-1 /-/-indazole-3-carboxylate as a pale tan solid (77 mg, 57 %); Rl 2.50 min (Method 2, acidic); m/z 680 (M-H)”, (ES”).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-(tert-Butyl)-1-(p-tolyl)-1H-pyrazol-5-amine, other downstream synthetic routes, hurry up and to see.