Synthetic Route of 39806-90-1,Some common heterocyclic compound, 39806-90-1, name is 4-Iodo-1-methyl-1H-pyrazole, molecular formula is C4H5IN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Dissolve 4-iodo-1-methyl-1H-pyrazole (1.37g, 6.59mmol) in THF (40mL), then add cuprous iodide (75mg, 0.198mmol) andBistriphenylphosphine palladium dichloride (140mg, 0.198mmol), replacing nitrogen three times, under nitrogen protection, slowly add diethylamine (7.5mL, 72.5mmol) and trimethylsilylacetylene (1.9mL, 13.2mmol, 0.69 g / mL).The reaction was stirred at room temperature for 20h.After the reaction was completed, saturated brine (100 mL) was added, extracted with ethyl acetate (50 mL ¡Á 3), the organic phases were combined, dried over anhydrous sodium sulfate, and the solvent was concentrated.Separation and purification by silica gel column chromatography (PE / EtOAc (v / v) = 20/1) to obtain 684 mg of light yellow liquid, yield: 58.2%.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Iodo-1-methyl-1H-pyrazole, its application will become more common.