Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 31108-57-3, name is 1H-Pyrazole-4-carbonitrile, A new synthetic method of this compound is introduced below., Application In Synthesis of 1H-Pyrazole-4-carbonitrile
To a solution of II-D4a (180 mg, 0.4 mmol) in acetone (5 mL) were added K2C03 (116 mg, 0.8 mmol) and lH-pyrazole-4-carbonitrile (78.7 mg, 0.8 mmol) at 25C. The reaction mixture was stirred for 12 hours at 25C. The reaction mixture was added into saturated NH4Cl (30 mL) and the aqueous layer was extracted with EtOAc (3 x 20 mL). The combined organic layer was washed with saturated brine (50 mL), dried over anhydrous Na2S0 , filtered and concentrated to give product. The residue was purified by flash column (10-20% of EtOAc in PE) to afford the product. The product was purified by prep-HPLC to afford II-D5a (59.6 mg, 32%) as a solid. (2696) 1H NMR (400 MHz, CDCl3) dH 7.85 (s, 1H), 7.81 (s, 1H), 4.95 (dd, J= 18.0, 49.6 Hz, 2H), 2.59 (t, J= 8.8 Hz, 1H), 2.25-2.13 (m, 1H), 2.07-2.01 (m, 1H), 1.92-1.82 (m, 1H), 1.80-1.60 (m, 7H), 1.55-1.12 (m, 15H), 1.05-0.90 (m, 2H), 0.85-0.75 (m, 4H), 0.65 (s, 3H); ELSD purity, 99%; MS ESI calcd. for C27H40N3O2 [M+H]+ 438, found 438
The synthetic route of 31108-57-3 has been constantly updated, and we look forward to future research findings.