Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 143426-52-2, name is 1-(4-(Chloromethyl)phenyl)-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 143426-52-2
Methyl 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)imidazo[1,2-a]pyridine-8-carboxylate (250 mg, 0.83 mmol, 1.0 eq.), 4-(1-pyrazolyl)benzyl chloride (319 mg, 1.7 mmol, 2.0 eq.), cesium carbonate (542 mg, 1.6 mmol, 2.0 eq.), Pd(dppf)Cl2.DCM (101 mg, 0.12 mmol, 0.15 eq.), THF (5.5 mL) and H2O (1 mL) were added into a microwave vial. The vial was evacuated and purged with N2 (3*). The mixture was stirred at 90 C. After 1 h, the mixture was cooled to r.t., filtered through a pad of Celite which was rinsed thoroughly with EtOAc/DCM/MeOH. The filtrate was concentrated and purified using column chromatography on silica gel (0-50% DCM/EtOAc for 15 min then 50-100% of 10% MeOH/DCM solution) to provide the title compound with some impurities. Further purification was conducted using RP-HPLC (25-60% MeCN in 0.05% NH4OH aqueous solution over 20 min). The desired fractions were concentrated to provide the title compound as a tan solid (170 mg, 62%). 1H-NMR (400 MHz, DMSO) delta 8.73 (s, 1H), 8.46 (d, J=2.4 Hz, 1H), 8.04 (d, J=1.2 Hz, 1H), 7.81-7.78 (m, 2H), 7.72 (d, J=1.7 Hz, 2H), 7.63 (d, J=1.2 Hz, 1H), 7.44-7.42 (m, 2H), 6.53 (t, J=2.1 Hz, 1H), 4.06 (s, 2H), 3.87 (s, 3H); ES-MS [M+H]+=333.2.
According to the analysis of related databases, 143426-52-2, the application of this compound in the production field has become more and more popular.