Application of 5334-40-7, These common heterocyclic compound, 5334-40-7, name is 4-Nitro-1H-pyrazole-3-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
4-(octahydrocyclopentane[c]pyrrolylmethyl)-phenyl-1,2-diamine (4.0 g, 17.32 mmol), 4-nitro-1H-pyrazole-3-carboxylic acid (2.47 g) , 17.32mmol), EDC ¡¤ HCl (4.98g, 19.05mmol) and HOBt (3.4g, 19.05mmol) was dissolved in dry DMF (25mL) are stirred at room temperature overnight. The solvent was removed under reduced pressure, was added glacial acetic acid (40 mL), heated to reflux for 3h, the solvent was removed under reduced pressure, purified through the column, and then washed with methanol, methanol-insoluble product as a yellow solid that is, to give a yellow solid (0.90 g, 23.94percent).
Statistics shows that 4-Nitro-1H-pyrazole-3-carboxylic acid is playing an increasingly important role. we look forward to future research findings about 5334-40-7.