These common heterocyclic compound, 1202993-11-0, name is 5-Chloro-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 5-Chloro-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid
-Chloro-3-(difluoromethyl)-l-methyl-lH-pyrazole-4-carbonyl chloride (Example lie)(lib) (l ie)3.2 g of 5-chloro-3-(difluoromethyl)-l-methyl-lH-pyrazole-4-carboxylic acid and 44.3 mL of thionyl chloride were heated under reflux for 5 h. After cooling, the reaction mixture was concentrated under reduced pressure, giving 3.5 g of 5-chloro-3-(difluoromethyl)-l-methyl-lH-pyrazole-4-carbonyl chloride as a yellow oil. NMR (400 MHz, CHC13- 6) delta ppm : 3.97 (s, 3H); 7.00 (t, J= 52.01 Hz, 1 H);IR (TQ): 1759 and 1725 cnT (C=0);
The synthetic route of 5-Chloro-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid has been constantly updated, and we look forward to future research findings.