Synthetic Route of 127107-23-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 127107-23-7, name is 1-Methyl-1H-pyrazol-4-amine hydrochloride belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
Into a 25 mL round-bottom flask were placed intermediate 48.3 (330 mg, 0.84 mmol, 1.00 equiv), n-BuOH (10 mL) and 1-methyl-1H-pyrazol- 4-amine hydrochloride (170 mg, 1.27 mmol, 1.20 equiv). The reaction was stirred overnight at110 C in an oil bath. The resulting mixture was concentrated under vacuum, diluted with sodium carbonate (1 mol/L) and extracted with 3 x 20 mL of DCE/IPA (3:1). The organic layers were combined, dried over anhydrous sodium sulfate and concentrated under vacuum. The crude product was purified by preparative HPLC to furnish 81.7 mg (21%) of compound 1-49 as an off-white solid. LCMS: 455 [M+H] ?H NMR: (300MHz, CD3OD): oe 7.518-7.817 (2H, s), 3.998 (1H, s), 3.836 (1H, d), 3.888 (4H, s), 3.5083.781 (4H, t), 2.6062.636 (4H, t), 2.2062.321 (6H, m), 1.1741.490 (8H, m).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Methyl-1H-pyrazol-4-amine hydrochloride, other downstream synthetic routes, hurry up and to see.