These common heterocyclic compound, 14531-55-6, name is 3,5-Dimethyl-4-nitro-1H-pyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of 3,5-Dimethyl-4-nitro-1H-pyrazole
3,5-dimethyl-4-nitro-1 H-pyrazole (201 mg, 1.4 mmol), K2CO3 (411 mg, 3.0 mmol), CuI (13.6 mg, 0.07 mmol),trans-N,N-dimethylcyclohexyldiamine (44.8 mL, 0.3 mmol) were 3-iodotoluene (528 mL, 4.1 mmol) were combined in amicrowave vial and irradiated for 4 h to 195 C in the microwave. The reaction mixture was filtered through celite, washedwith EtOAc, concentrated in vacuo and was purified by column chromatography (10% EtOAc in PE) to yield 233 mg(71%) of the title compound.
The synthetic route of 3,5-Dimethyl-4-nitro-1H-pyrazole has been constantly updated, and we look forward to future research findings.