Adding a certain compound to certain chemical reactions, such as: 15366-34-4, name is Methyl 1H-pyrazole-3-carboxylate, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 15366-34-4, Recommanded Product: 15366-34-4
Methyl 1H-pyrazole-3-carboxylate (0.500 g, 3.96 mmol) was dissolved in dry MeCN (30 mL), then (bromomethyl)cyclopropane (0.46 1 mL, 4.76 mmol) was added,followed by cesium carbonate (1.94 g, 5.95 mmol). The reaction mixture was stirred at 60C for 2 h. The reaction mixture was cooled to rt and diluted with EtOAc. ThenCELITE was added, and the solvent was removed under reduced pressure. The residue was purified by flash chromatography (solid loading on CELITE, 0-55% EtOAc/Hex) affording two products.Intermediate hA (0.197 g, 28% yield) as a colorless syrup eluted at 20%EtOAc. MS(ESI) m/z: 180.9 (M+H) ?HNMR: (500 MHz, CDC13) oe ppm 7.49 (d, J1.9 Hz, 1H), 6.84 (d, J=1.9 Hz, 1H), 4.44 (d, J=7.2 Hz, 2H), 3.88 (s, 3H), 1.44 – 1.31 (m,1H), 0.57 – 0.48 (m, 2H), 0.45 – 0.37 (m, 2H).Intermediate 12A (0.4 15 g, 58% yield) as a colorless syrup eluted at 42%EtOAc. MS(ESI) m/z: 180.9 (M+H) ?H NMR: (500 MHz, CDC13) oe ppm 7.54 (d, J2.5Hz, 1H), 6.84 (d, J=2.5 Hz, 1H), 4.07 (d, J=7.2 Hz, 2H), 3.93 (s, 3H), 1.32 (quint, J7.6,4.9 Hz, 1H), 0.71 – 0.64 (m, 2H), 0.45 – 0.36 (m, 2H).
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