Reference of 2458-26-6, These common heterocyclic compound, 2458-26-6, name is 3-Phenyl-1H-pyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: To a 25ml two-necked round-bottom flask was placed a mixture of aryl iodide (1mmol), indole (1.5mmol), CuI (0.1mmol), K2CO3 (2mmol), and DMSO (1mmol) in 2ml glycerol. The reaction mixture was heated in an oil bath at 120C for 24h with continuous stirring. After completion of reaction monitored by TLC, the reaction mixture was cooled to room temperature and was extracted with diethyl ether three times (3¡Á10ml). The combined organic layers were washed with brine solution and dried over anhydrous Na2SO4 and concentrated in vacuo. The crude product was purified by column chromatography on silica gel (60-120 mesh) to provide the N-aryl indole in 88% yield. The remaining glycerol/copper catalytic mixture was reused for further recycling study by adding fresh DMSO (1mmol) to the catalytic system. All the products are well known in the literature and were confirmed by comparison of their spectroscopic data with literature data.
The synthetic route of 2458-26-6 has been constantly updated, and we look forward to future research findings.