Related Products of 1145-01-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1145-01-3, name is 3,5-Diphenyl-1H-pyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
A mixture of 3,5-diphenylpyrazole (1) (0.0927 g, 0.42 mmol) and Selectfluor (0.34 g, 0.97 mmol) in non-dried, stock-grade acetonitrile (1.5 mL) was heated at 80 C (oil bath temp) in an open atmosphere for 2 h and 20 min (140 min) and then cooled. Water was added to the dark yellow solution followed by extraction with EtOAc. The organic layers were combined and dried over Na2SO4 and filtered. The filtrate was evaporated onto silica gel and subjected to flash chromatography on silica gel using 10:1 hexanes/EtOAc as eluent to give first difluoropyrazole 2 (0.031 g, 29%) and then hydrated difluoropyrazole 3 (0.077 g, 67%) as yellow solids.
The synthetic route of 3,5-Diphenyl-1H-pyrazole has been constantly updated, and we look forward to future research findings.