Electric Literature of 3994-50-1,Some common heterocyclic compound, 3994-50-1, name is 1-Methyl-4-nitro-1H-pyrazole, molecular formula is C4H5N3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A mixture of l-methyl-4-nitro-lH-pyrazole (1.10 g, 8.66 mmol) and Pd-C (10%, 190 mg) in EtOAc (20 mL) (containing 8 drops of 6N HC1) was hydrogenated under balloon H2 for 18 h. After being filtered through celite, the filtrate was concentrated in vacuo. The residue was dissolved in IN HC1 (20 mL), then washed with hexane, concentrated in vacuo to give 1 -methyl- lH-pyrazol-4-amine dihydrochloride as a solid (0.918 g).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Methyl-4-nitro-1H-pyrazole, its application will become more common.