Electric Literature of 37687-24-4, A common heterocyclic compound, 37687-24-4, name is Diethyl 3,5-pyrazoledicarboxylate, molecular formula is C9H12N2O4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 41; (5R, 6E&Z)-7-oxo-6- (4H, 10H-pyrazolo [5, 1-c] [1, 4] benzoxazepin-2-ylmethylene)-4- thia-1-azabicyclo [3. 2. 0] hept-2-ene-2-carboxylic acid, sodium salt Step 1: Preparation of 1-(2-fluorobenzyl)-1H-pyrazole-3,5-dicarboxylate 2-fluorobenzyl bromide (2.0 ml, 16.58 mmol) was added to a mixture of diethyl 3,5- pyrazoledicarboxylate (3.01 g, 14.18 mmol), Cs2CO3 (5.57 g, 17.1 mmol), and acetonitrile (140 ml) under N2. Heated to 60C for two hours and then cooled to room temperature. Filtered and concentrated the reaction solution. Added water (-200mL) to the resulting residue and extracted with EtOAc. Washed organics with water and brine. Dried organics over sodium sulfate and filtered and concentrated. Obtained diethyl 1- (2- fluorobenzyl)-1 H-pyrazole-3, 5-dicarboxylate (light-yellow oil) in quantitative yield.
The synthetic route of 37687-24-4 has been constantly updated, and we look forward to future research findings.