2458-26-6, name is 3-Phenyl-1H-pyrazole, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Formula: C9H8N2
General procedure: A mixture of acetophenone and dimethylformamide dimethylacetal (2.0 equiv.) was refluxed overnight. The reaction mixture was allowed to cool down to room temperature and was concentrated under reduced pressure. The remaining residue was suspended in hexanes and filtered. The filter cake was washed with plenty of hexanes. (E)- 3-(dimethylamino)-l- phenylprop-2-en-l-one was obtained. (0260) Hydrazine-monohydrate (5.0 equiv.) was added to a solution of (E)- 3- (dimethylamino)-l-phenylprop-2-en-l-one in EtOH and the resulting reaction mixture was refluxed for 2 hours. The reaction was then allowed to cool down to room temperature and was concentrated under reduced pressure. The remaining residue was diluted with H2O and extracted with CH2CI2. The organic phase was dried over MgS04, filtered and concentrated under reduced pressure. The residue was considered pure enough by -NuMuKappa (>95%) to be used without further purification. (0261) A mixture of phenylpyrazole, iodoarene (1.0 equiv.), copper iodide (20 mol%), trans- (0262) 1,2-diaminocyclohexane (25 mol%), potassium carbonate (2.0 equiv.) in dioxane was stirred at 100C under argon for 16 hours. After cooling down to room temperature, the reaction mixture was diluted with H2O and extracted with EtOAC. The gathered organic phases were washed with NH4CI/NH3 (v/v : 1/1), brine, dried over MgSC , filtered and concentrated under reduced pressure. The remaining residue was purified by column chromatography on silica gel (Hexanes/EtOAc).
The synthetic route of 2458-26-6 has been constantly updated, and we look forward to future research findings.