Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5932-27-4, name is Ethyl 1H-pyrazole-3-carboxylate, A new synthetic method of this compound is introduced below., Application In Synthesis of Ethyl 1H-pyrazole-3-carboxylate
Description 43; Ethyl 1 -[(3-bromo-4-cyanophenyl)methyl]-1 H-pyrazole-3-carboxylate (D43); A suspension of ethyl 1 H-pyrazole-3-carboxylate (D1 ) (3.298g, 0.024 mol), 4- (bromomethyl)-2-bromobenzonitrile (D42) (6.48g, 0.024 mol) and potassium t- butoxide (2.903g, 0.026 mol), in ethanol (250ml) was heated at 6O0C overnight. The reaction mixture was concentrated in vacuo and dissolved in water (~250ml) and ethylacetate (-25OmI), the layers were partitioned and the aq was washed twice with ethylacetate (2x 100ml). The combined organics were passed through a phase separating cartridge to dry and concentrated in vacuo. The residue was scratched down and stirred in ethylacetate (~50ml) and the resultant solid was filtered off. The mother liquors were concentrated in vacuo and purified by Biotage SP4 with 4OM cartridge and 30-70percent ethylacetate/hexane as eluant. The product containing fractions were combined and concentrated. This product was combined with the first crop to yield the title compound as a white solid (1.55g, 4.6 mmol). MS (ES+): requires C14H1279BrN3O2 333; found 334 (M+H+).
The synthetic route of 5932-27-4 has been constantly updated, and we look forward to future research findings.