Application of 14521-80-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 14521-80-3 name is 3-Bromo-1H-pyrazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a solution of 3-bromo-1H-pyrazole (5.39 g, 36.67 mmol) and triphenylchloromethane (10.40 g, 37.41 mmol) in DCM (300 ml) was added trimethylamine (7.41 g, 73.37 mmol). The reaction mixture was heated at 50 00 for 18 hours (overnight). After this time, the mixture was concentrated under reduced pressure and chromatographed [Si02] to give 3-bromo-1-trityl-pyrazole (P17) (8.97 g).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Bromo-1H-pyrazole, and friends who are interested can also refer to it.