Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1280210-79-8, name is tert-Butyl 4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate, A new synthetic method of this compound is introduced below., Formula: C10H15N3O2
3 -(Bromomethyl)- 1,1 -difluoro-cyclobutane (505 mg, 2.73 mmol) was added dropwisc over 15 mm, to a mixture of tert-butyl 4,6-dihydro-2H-pyrrolo[3,4- c]pyrazole-5-carboxylate (560 mg, 2.67 mmol), cesium carbonate (1.39 g, 4.28 mmol) and DMF (5 mL) at 0 C. The reaction mixture was allowed to warm to ambient temperature and stirred for 18 h. The solvent was concentrated and the material was partitioned betweenwater (50 mL) and EtOAc. The aqueous layer was washed with EtOAc (2 x 30 mL). The combined organic layers were washed with brine, dried (MgSO4), and the solvent was concentrated. Purification (FCC, Si02 using ether) provided the title compound (344 mg, 41%). ?H NMR (300 MHz, CDC13) 3 = 7.10 (d, J = 10.0 Hz, 1H), 4.50 -4.37 (m, 4H), 4.18 (d, J = 5.5 Hz, 2H), 2.78-2.56 (m, 3H), 2.47-2.25 (m, 2H), 1.50 (s, 9H); [M+H] = 314.26.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.