These common heterocyclic compound, 15366-34-4, name is Methyl 1H-pyrazole-3-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 15366-34-4
To a solution of A/-(2-bromophenyl)quinolin-3-amine (164 mg, 0.55 mmol) in DMF (2.5 mL), were added methyl 7/- -pyrazole-3-carboxylate (63 mg, 0.50 mmol), copper(l) iodide (10 mg, 0.05 mmol), L- proline (12 mg, 0.10 mmol) and potassium phosphate (212 mg, 1.0 mmol). The mixture was stirred at 120 C for 18 h. The crude mixture was purified by preparative HPLC (CH3CN/H2O) to afford the title compound as a yellow solid (80 mg, 42%). LogP = 2.16 [Method A]. Mass (M+H) = 345. Purity = 99% (LC-210nm).
The synthetic route of Methyl 1H-pyrazole-3-carboxylate has been constantly updated, and we look forward to future research findings.