Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1191616-45-1, name is 4-(4-Bromophenyl)-1-methyl-1H-pyrazole, A new synthetic method of this compound is introduced below., SDS of cas: 1191616-45-1
Compound 6c (1.5g, 5.0mmol), 4-(4-bromophenyl)-1-methyl-1H-pyrazole (1.2g, 5.0mmol), catalyst Pd(dba) 2 (144mg, 0.25mmol) , Tri-tert-butylphosphine (101mg, 0.5mmol), sodium tert-butoxide (576mg, 6.0mmol) were dissolved in toluene (50ml), heated to 100 and stirred for 12 hours, TLC detection reaction, direct concentration column chromatography separation 1.6 g of off-white solid was obtained with a yield of 69.3%.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.