Some common heterocyclic compound, 31037-02-2, name is Ethyl 5-amino-1-methyl-1H-pyrazole-4-carboxylate, molecular formula is C7H11N3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 31037-02-2
Triethylamine (0.49 ml, 3.5 mmol) was added to a stirred solution of ethyl 5-amino-1-methyl-pyrazole-4- carboxylate (0.50 g, 3.0 mmol) in dichloromethane (30 ml) at 0C. After 5 minutes methanesulfonyl chloride (0.23 ml, 3.0 mmol) was added dropwise. The resulting mixture was allowed to warm to room temperature over 18 hours and then partitioned between 1 M hydrochloric acid and dichloromethane. Thephases were separated and the aqueous extracted with further dichloromethane. The combined organic phases were passed through a PhaseSep cartridge and concentrated under reduced pressure to leave ethyl 5-(methanesulfonamido)-1-methyl-pyrazole-4-carboxylate, which was used without further purification. Characterising data for the compound are as follows: 1H NMR (400 MHz, CDCI3) oe 7.97 (s, 1 H), 4.34 (t,2H), 3.92 (s, 3H), 3.51 (s, 3H) and 1.36 (t, 3H) ppm.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 31037-02-2, its application will become more common.