Reference of 73387-46-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 73387-46-9 name is 3-(4-Bromophenyl)-1H-pyrazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
[0001228] A mixture of 3-(4-bromophenyl)-lH-pyrazole (1.0 g, 4.5 mmol), cyclopropylboronic acid (0.8 g, 9 mmol), Cu(OAc)2 (1.6 g, 9 mmol), Na2C03 (0.9 g, 9 mmol), bipyridine (1.4 g, 9 mmol), and 4 A molecular sieve powder (5 g) in 1,2- dichloroethane (20 mL) was stirred at 30 C for 72 h. After filtration, the mixture was diluted with dichloromethane (50 mL), washed with water (30 mL x 2) and brine (50 mL), dried over anhydrous sodium sulfate, and concentrated to give a crude compound. The crude product was purified with flash column chromatography on silica gel (ethyl acetate in petroleum ether, from 0% to 10% v/v) to afford Compound 349A.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-(4-Bromophenyl)-1H-pyrazole, and friends who are interested can also refer to it.