Application of 105434-90-0,Some common heterocyclic compound, 105434-90-0, name is Ethyl 5-amino-1H-pyrazole-3-carboxylate, molecular formula is C6H9N3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a mixture of compound 226-1 (1.0 g, 6.45 mmol) in THF (10 mL) was added LiBH4 (8.0 mL,16.01 mmol, 2M in THF) drop- wisely at 0 oC and the reaction was stirred at 60 oC overnight. After completion of the reaction, the reaction mixture was quenched with MeOH and concentrated to dryness under reduced pressure. The residue was purified by column chromatography on silica gel (DCM: MeOH = 80: 1 to 20: 1) to give compound 2 (600 mg, yield 82.3%) as white solid. LC/MS (ESI) m/z: 114 (M+H)+.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Ethyl 5-amino-1H-pyrazole-3-carboxylate, its application will become more common.