Adding a certain compound to certain chemical reactions, such as: 391-77-5, name is 4-Chloro-6-fluoroquinoline, belongs to quinolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 391-77-5, name: 4-Chloro-6-fluoroquinoline
4-Chloro-6-fluoro-quinoline (50 mg), 5,6-dimethyl-[2,2′]bipyridinyl-3-ol (55 mg), and 4-dimethylaminopyridine (101 mg) were dissolved in dimethylsulfoxide (1.5 ml), cesium carbonate (269 mg) was added to the suspension, and the mixture was stirred at 130C overnight. The reaction mixture was cooled to room temperature, and water was added thereto. The organic layer was extracted with chloroform, and the chloroform layer was then washed with water and saturated brine and was dried over anhydrous sodium sulfate. The solvent was removed by distillation under the reduced pressure, and the residue was purified by thin layer chromatography with a methanol-chloroform system to give the title compound (87 mg, yield 90%). 1H-NMR (CDCl3, 400 MHz): delta 2.41 (s, 3H), 2.67 (s, 3H), 6.51 (d, J = 3.7 Hz, 1H), 7.10 (ddd, J = 1.0, 4.9, 7.6 Hz, 1H), 7.38 (s, 1H), 7.54 – 7.64 (m, 2H), 7.90 (d, J = 7.6 Hz, 1H), 7.98 (dd, J = 2.7, 9.0 Hz, 1H), 8.21 (m, 1H), 8.36 (m, 1H), 8.54 (d, J = 5.4 Hz, 1H) Mass spectrometric value (ESI-MS, m/z): 368 (M+Na)+
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