Synthetic Route of 63149-33-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 63149-33-7 name is 8-Hydroxy-1,2,3,5,6,7-hexahydropyrido[3,2,1-ij]quinoline-9-carbaldehyde, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Sensor 1 was prepared by the reaction of 8-hydroxyjulolidine-9-carboxaldehyde (0.22 muL, 1.0 mmol) and furan-2-carbohydrazide (0.13 g, 1.0 mmol) in ethanol. Two drops ofHCl were added into the reaction solution, which was stirredfor 2 days at room temperature. A yellow precipitate was filtered,washed several times with cold ethanol, and dried invacuum. Yield: 0.29 g (89%). The 1H NMR spectra wererecorded in DMSO-d6, and the descriptions of the signalsinclude: s = singlet, d = doublet, t = triplet and m = multiplet(400 MHz, 25 C): delta = 11.82 (s, 1H), 11.66 (s, 1H), 8.29 (s,1H), 7.91 (d, 1H), 7.22 (d, 1H), 6.68 (d, 2H), 3.16 (m, 4H),2.48 (m, 4H), 1.84 (m, 4H); 13C NMR (100 MHz, CD3CN,25 C): delta = 154.91, 153.72, 151.35, 145.75, 128.56, 115.23,112.31, 106.07, 49.61, 26.82, 21.23. IR (KBr, nu cm-1) = 3209(m), 2938 (m), 2839 (m), 2361 (m), 2160 (m), 1627 (m), 1590(s), 1507 (s), 1461 (m), 1349 (m), 1292 (s), 1174 (s), 1086(m), 1013 (m), 968 (m), 844 (m), 744 (s), 662 (s). Anal. calcdfor C18H19N3O3: C, 66.45; H, 5.89; N, 12.91%. Found: C,66.27; H, 5.94; N, 12.83%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 8-Hydroxy-1,2,3,5,6,7-hexahydropyrido[3,2,1-ij]quinoline-9-carbaldehyde, and friends who are interested can also refer to it.