Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 3279-90-1, name is 6-Bromo-3,4-dihydro-1H-quinolin-2-one, A new synthetic method of this compound is introduced below., Application In Synthesis of 6-Bromo-3,4-dihydro-1H-quinolin-2-one
Under nitrogen protection,100mL three bottles,The compound 6-bromo-3,4-dihydroquinolin-2 (1H) -one (2.5 g, 11.06 mmol)And N, N-dimethylformamide (2.5 g, 11.06 mmol) were dissolved in dry tetrahydrofuran (50 mL) and cooled to -78 C.A solution of tert-butyllithium (24.1 mL, 38.7 mmol, 1.6 M in pentane) was slowly added dropwise,After completion of the dropwise addition, the reaction was continued at -78 C for 4 hours,Acetic acid (2.5 mL) was added and the temperature was slowly warmed to room temperature.The reaction solution was diluted with ethyl acetate (100 mL) and washed successively with saturated sodium bicarbonate solution and brine. The organic phase was dried, filtered and concentrated to give 2-oxo-1,2,3,4-tetrahydroquinoline-6-carbaldehyde (0.6 g) in 30% yield.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.