Brief introduction of 133228-21-4

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Adding a certain compound to certain chemical reactions, such as: 133228-21-4, name is N,N-Dimethyl-1H-pyrazole-1-sulfonamide, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 133228-21-4, Safety of N,N-Dimethyl-1H-pyrazole-1-sulfonamide

Step 2: Preparation of 3-bromo-pyrazole-l-sulfonic acid dimethylamide; Pyrazole-1-sulfone acid dimethylamide (17.6 g) was dissolved in dry THF (200 mL) and cooled to -78C. A solution of n-butyllithium (80 mL, 1.3 M) was added slowly over a period of 15 min and stirred for further 15 min at – 78C. A solution of 1, 2-dibromo-l, 1, 2 , 2-tetrachloroethane(35.8 g) in dry THF (60 mL) was added within 10 min to this solution and stirred for further 15 min at -78C, then the cool bath was removed and the mixture was quenched with water after stirring for 1 h. The reaction mixture was extracted 3x with ethyl acetate, the combined org. layers were washed with brine, dried over MgSO4 and concentrated in vacuum.The residue was purified by column chromatography (silica gel 60, hexane/ethyl acetate = 5:1, Rf = 0.25) to afford 21.3 g of the title compound of the formulae2 as a colorless oil.1H-NMR (CDCl3, TMS) delta (ppm) : 3.08 (6H, s) , 6.43 (IH, m) , 7.61 IH, m) .

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