Reference of 1008-79-3, The chemical industry reduces the impact on the environment during synthesis 1008-79-3, name is 1-Phenyl-1H-pyrazol-3(2H)-one, I believe this compound will play a more active role in future production and life.
A solution of 3-hydroxy-1-methyl-1H-pyrazole (1) [ 38 ] (710mg, 7.2mmol) in dry DMF (20mL) was cooled to 0C under inert atmosphere and NaH (60% dispersion in mineral oil, 290mg, 7.2mmol) was added portion wise. After stirring mixture for 15min benzyl chloride (0.82mL, 7.2mmol) was added drop wise. The mixture was stirred at 60C for 1h, then poured into water and extracted with ethyl acetate. The organic layers were combined, washed with brine, dried over Na2SO4, filtrated, and the solvent was evaporated. The residue was purified by column chromatography (SiO2, eluent: ethyl acetate/n-hexane, 1:7, v/v) to give pure 3 as a brown liquid. Yield 90%, 1205mg.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Phenyl-1H-pyrazol-3(2H)-one, other downstream synthetic routes, hurry up and to see.