Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 83-10-3, name is 1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid, A new synthetic method of this compound is introduced below., Application In Synthesis of 1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid
To a solution of 4-((7-methoxyquinolin-4-yl)oxy)aniline (4 g, 15 mmol) and l,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-lH-pyrazole-4-carboxylic acid (3.56 g, 18 mmol) in CH2C12 (42 mL) was added HOAT (0.41 g, 3 mmol) at 43 C. The reaction was stirred at 43 C overnight, then cooled to rt and diluted with CH2CI2 (42 mL). The organic phase was separated, washed with water (42 mL x 2), dried over Na2S04 and concentrated in vacuo. The residue was stirred in EtOH aqueous solution (20 mL of EtOH in 20 mL of water) at rt for 3 h and collected through filtration to afford the title compound as a light yellow solid (5.6 g, 77.6%). MS (ESI, pos, ion) m/z: 481.0 [M+H]+; NMR (400 MHz, CDC13): delta 2.80 (s, 3H), 3.36 (s, 3H), 3.96 (s, 3H), 6.45 (d, J= 5.3 Hz, 1H), 7.11-7.13 (m, 2H), 7.20 (dd, J= 2.5 Hz, 9.2 Hz, 1H), 7.35 (t, J= 1.1 Hz, 2.2 Hz, 1H), 7.38 (d, J= 1.4 Hz, 1H), 7.41 (d, J= 2.5 Hz, 1H), 7.46-7.49 (m, 1H), 7.55 (t, J= 7.3 Hz, 15.2 Hz, 2H), 7.75 (dd, J= 2.1 Hz, 6.8 Hz, 2H), 8.24 (d, J = 9.2 Hz, 1H), 8.57 (d, J= 5.3 Hz, 1H), 10.77 (s, 1H).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.