Related Products of 110860-60-1,Some common heterocyclic compound, 110860-60-1, name is Methyl 5-amino-1-methyl-1H-pyrazole-4-carboxylate, molecular formula is C6H9N3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
[Example 6] Production of (Pig-8): 6.8 Parts of the compound represented by formula (6) was added to a mixed solvent consisting of 28.7 parts of acetic acid, 5.1 parts of propionic acid and 1.8 parts of water and dissolved. This solution was ice-cooled to 5C, and 13.1 parts of 43% nitrosylsulfuric acid solution was added. During the addition, the temperature of the system climbed to 25C. After the addition of nitrosylsulfuric acid, a diazotization reaction was performed at 25C. After stirring for 1.5 hours, the reaction solution was cooled to 15C, and the excess nitrosylsulfuric acid was deactivated with urea to obtain a diazonium compound liquid preparation (step (a)). A solution obtained by adding and completely dissolving 7.4 parts of the compound represented by the following formula (9) in a mixed solution of 64.9 parts of acetic acid and 37.1 parts of sulfuric acid was prepared, and this solution was added to the diazonium compound liquid preparation above at 20C or less. After the completion of addition, the reaction was allowed to proceed at 20C for 1 hour to obtain an azo compound solution. During the reaction, precipitation of the pigment was not observed (that is, this solution was in a state of the obtained azo compound being completely dissolved) (step (b)). A poor solvent consisting of 210 parts of methanol and 30 parts of water was prepared and stirred at 15C and 250 rpm. In this poor solvent, the azo compound solution above was added dropwise (step (c)). After stirring as-is for 5 minutes, 292 parts of water was added and the produced powder was separated by filtration. The powder was added to 270 parts of water, and the excess acid was neutralized with aqueous ammonia. Filtration and water washing were again performed to obtain 12.5 parts (yield: 89.0%) of (Pig-8). The obtained pigment powder was observed with an eye through a transmission microscope (Electron Microscope JEM-1010, manufactured by JEOL Ltd.), as a result, the length in the long axis direction of the primary particle was 130 nm. Fig. 3 shows the IR spectrum of Pig-8.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 5-amino-1-methyl-1H-pyrazole-4-carboxylate, its application will become more common.