Electric Literature of 5932-30-9, A common heterocyclic compound, 5932-30-9, name is Ethyl 5-phenyl-1H-pyrazole-3-carboxylate, molecular formula is C12H12N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: Compound ethyl 1H-indole-2-carboxylate (0.1g, 0.53 mmol) was added to a solution of 6h (0.29 g, 2.6 mmol) in EtOH (10 mL) at ambient temperature. The reaction was refluxed for 6 h and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography to yield the target product 1. (yield: 77%). 1H NMR (400 MHz, DMSO-d6) delta 11.74 (s, 1H), 11.44 (s, 1H), 7.66 (t, J = 6.3 Hz, 2H), 7.45 (d, J = 8.3 Hz, 1H), 7.35 – 7.11 (m, 2H), 7.06 (t, J = 7.6 Hz, 1H), 2.28 (s, 1H), 1.87 – 1.60 (m, 3H), 1.38 – 1.21 (m, 7H). 13C NMR (400 MHz, DMSO-d6) delta 157.90, 130.67, 127.46, 124.06, 122.10, 112.79, 103.54, 30.22, 29.13, 28.12. HRMS(ESI) m/z calculated for C16H19N3O [M+Na]+:292.1426, found 292.1420.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.