Adding a certain compound to certain chemical reactions, such as: 27258-32-8, name is 1-Methyl-1H-pyrazole-3-carbaldehyde, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 27258-32-8, SDS of cas: 27258-32-8
To a solution of 1-methyl-1H-pyrazole-3-carbaldehyde (150 g, 1.36 mol) in DMF (1000 mL) was added NBS (240 g, 1.35 mol). The resulting solution was stirred for 2 h at 50¡ã C. and then was quenched by the addition of ice water (2000 mL). The reaction mixture was cooled to ?10¡ã C. with an ice/salt bath, and the solids were collected by filtration to provide the desired product as a white solid (200 g, 78percent). 1H NMR (300 MHz, CDCl3): delta 9.90 (d, J=0.7 Hz, 1H), 7.46 (s, 1H), 3.96 (s, 3H) ppm.
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