In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1082745-50-3, name is 5-Amino-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole-4-carboxamide belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Computed Properties of C9H14N4O2
To a suspension of 0.132 g (0.63 mmol) of 5-amino-1-(tetrahydro-pyran-4-yl)-1-H-pyrazole-4-carboxylic acid amide (see PCT patent application WO2010/026214) in dry EtOH (1.5 mL), 0.066 g (1.66 mmol) of sodium hydride (60% suspension in mineral oil) were added at room temperature under nitrogen. After 10 min, 0.181 mg (0.945 mmol) of Example 13A were added and the reaction mixture was heated to 140 C. for 40 min in a microwave oven (Power 100W). The reaction mixture was then diluted with DCM, water was added, organics separated and dried over sodiumsulphate. Organics were evaporated under reduced pressure and the crude purified by flash chromatography (DCM/IPA 98:2) to obtain the title compound as a white solid. (54 mg, 32%).HPLC-MS (Method 1Eh): Rt=8.01 minMS (APCI pos): m/z=352 (M+H)+ The enantiomers of the title compound were separated by HPLC using a chiral stationary phase.Method for Enantioseparation:Semipreprative Conditions: HPLC semipreparative system: Waters 600 pump; column: Daicel chiralcel OJ-H, 250 mmx20 mm, 5.0 mum; eluent: hexane/EtOH85:15; flow rate: 15 mL/min, Temperature: 25 C.; UV Detection: 254 nm Analytical ConditionsHPLC apparatus type: Agilent 1100; Method 6.1; column: Daicel chiralcel OJ-H, 250 mmx4.6 mm, 5.0 mum; eluent: hexane/EtOH85:15; flow rate: 1 mL/min, Temperature: 25 C.; UVDetection: 254 nm
The synthetic route of 1082745-50-3 has been constantly updated, and we look forward to future research findings.