Related Products of 2458-26-6, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2458-26-6, name is 3-Phenyl-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows.
To a solution of ethyl2-chloronicotinate (2 g, 10.78 mmol) and 3-phenyl-1H-pyrazo1e (2.33 g, 16.16 mmol) in DMF (30 mL) was added K2C03 (4.47 g, 32.33 mmol)and Kl (1.79 g, 10.78 mmol). The mixture was stirred at 130 oc for 16h. The reaction wasfiltered, the filtrate was added I-hO (100 mL), extracted with EA (30 mL x2), the organicphase was washed with brine ( l 00 mL ), filtered, and concentrated. The residue was purifiedby flash silica gel chromatography (ISCO; 40 g SepaFlash Silica Flash Column, Eluent of15(% Ethyl acetate/Petroleum ethergradient 40 mUmin). Compound 113A (1 g, yield:28.5%) was obtained as a white solid. 1H NMR (400MHz, CDCh) 8 8.49 (dd, J = 1.7, 4.6Hz, lH), 8.42 (d, J”‘ 2.4 Hz, 1H), 7.94 (dd, J ‘” 1.7, 7.6 Hz, lH), 7.89- 7.78 (m, 2H), 7.40 (t,J “‘ 7.3 Hz, 2H), 7.33 (br d, J ‘” 7.3 Hz, H-I), 7.29 – 7.23 (m, HI), 6.79 (d, J “‘ 2.7 Hz, HI),4.45- 4.25 (m, 2H), 1.14 (t, J = 7.2 Hz, 3H). MS (ESl) m/z (M+Ht294.1.
The chemical industry reduces the impact on the environment during synthesis 3-Phenyl-1H-pyrazole. I believe this compound will play a more active role in future production and life.