Synthetic Route of 1000895-26-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1000895-26-0, name is (5-Amino-1H-pyrazol-3-yl)methanol belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
To a mixture of 2,4,6-trichloropyrimidine (8.0 g, 43.7 mmol) and (3-amino-1H-pyrazol-5-yl)methanol (7.4 g, 65.4 mmol) in EtOH (80 mL) was added DIPEA (11.3 g, 87.2 mmol). The reaction mixture was stirred at 20 C. for 12 h and filtered to give the title intermediate (6.5 g, 57% yield) as a white solid. (m/z): [M+H]+ calcd for C8H7Cl2N5O 260.00 found 260.0.
The synthetic route of (5-Amino-1H-pyrazol-3-yl)methanol has been constantly updated, and we look forward to future research findings.