These common heterocyclic compound, 86477-09-0, name is Ethyl 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-2-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 86477-09-0
Add 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-2-carboxylic acid ethyl ester (3.10 g, 17.2 mmol) and 30 mL of water to a 100 mL vial and cool to 0 C.Add sodium hydroxide solid (4.8 g, 86.0 mmol), stir to dissolve,Transfer to room temperature for 3 h, TLC detection reaction is completed,Wash once with 30 mL of DCM, adjust the pH of the aqueous phase to about 5 with concentrated hydrochloric acid.A white solid is precipitated and suction filtered to obtain a part of the product.The filtrate was extracted 3 times with 50 mL of EA, and the organic phases were combined and dried over anhydrous sodium sulfate.Filtered, concentrated,A total of 1.7g of light yellow solid, a yield of 65%,
The synthetic route of Ethyl 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-2-carboxylate has been constantly updated, and we look forward to future research findings.