Reference of 175277-11-9, The chemical industry reduces the impact on the environment during synthesis 175277-11-9, name is 3-tert-Butyl-1-methylpyrazole-5-carboxylic Acid, I believe this compound will play a more active role in future production and life.
To a solution of 3-(t-butyl)-1-methyl-1H-pyrazole-5-carboxylic acid (0.054 g, 0.295 mmol) in dioxane (3 ml) was added TEA (0.123 ml, 0.885 mmol) followed by DPPA (0.095 ml, 0.442 mmol). The mixture was stirred at RT for 30 min and then treated with a solution of Example A3 (0.080 g, 0.295 mmol) in dioxane (3.00 ml). The reaction was then placed in an oil bath preheated to 100 C. and stirred with heating overnight. The completed reaction was cooled to RT. Without aqueous workup, the reaction mixture was purified directly by reverse phase chromatography (MeCN (w/0.1% TFA)/H2O (w/0.1% TFA)) to afford 1-(3-tert-butyl-1-methyl-1H-pyrazol-5-yl)-3-(2-fluoro-4-(2-(oxazol-2-yl)pyridin-4-yloxy)phenyl)urea of 96.8% purity. MS (ESI) m/z: 451.1 (M+H+).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-tert-Butyl-1-methylpyrazole-5-carboxylic Acid, other downstream synthetic routes, hurry up and to see.