Synthetic Route of 2075-45-8, These common heterocyclic compound, 2075-45-8, name is 4-Bromo-1H-pyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
4-Bromopyrazole (1. 0g, 6. [8MMOL)] and triethylamine (0. [90MOL,] 6. [5MMOL)] were stirred under nitrogen in DMF at [0C.] Trityl chloride (1.81g, 6. [5MMOL)] was added, and the mixture was stirred for two days at room temperature. The mixture was then diluted with chloroform (10 [ML),] and washed with water. The organic portion was dried over sodium sulphate and solvent evaporated in vacuo to give the crude product. The resulting solid was washed with di-isopropyl ether to give the title compound (1.55g) LCMS RT 4.09min, [CPh3] + 243
Statistics shows that 4-Bromo-1H-pyrazole is playing an increasingly important role. we look forward to future research findings about 2075-45-8.