In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 930-36-9, name is 1-Methylpyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Formula: C4H6N2
Step 1; [00116] q-Methyl-lH-pyrazol-5-yl)phihenyl)methanol: At about -78 0C, n- butyllithium (58.5 mL, 2.5M) was added to a solution of 1 -methyl- lH-pyrazole (10 g, 121.95 mmol, 1.00 equiv.) in tetrahydrofuran (200 mL). The mixture was stirred at about -78 0C for about 1 hour, and then benzaldehyde (14.2 g, 133.96 mmol, 1.10 equiv.) was added. The mixture was stirred at ambient temperature for about 16 hours, and then a saturated aqueous solution of ammonium chloride (100 mL) was added. Following standard extractive workup with ethyl acetate (2 x 100 mL), the resulting residue was purified by silica gel column chromotagraphy (ethyl acetate / petroleum ether (1:1)) to give the title product as a white solid (20.2 g; yield = 88%). LC-MS: m/z = 189 (MH)+. 1H NMR (300 MHz, CHCl3) delta: 7.26-7.38 (m, 6H), 6.00 (d, / = 1.8 Hz, IH), 5.85 (s, IH), 3.70 (s, 4H).
The synthetic route of 930-36-9 has been constantly updated, and we look forward to future research findings.