Adding a certain compound to certain chemical reactions, such as: 18048-64-1, name is 1-(3,4-Dimethylphenyl)-3-methyl-1H-pyrazol-5(4H)-one, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 18048-64-1, HPLC of Formula: C12H14N2O
Take 11.5g82.4%) of 3′-amino-2′-hydroxybiphenyl-3-formic acid(VI) obtained in step ( 2), (6.8 g, 82.4%) 2-(3,4-dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one (VII) was added, condensation and cyclization reactions took place, and then Ethanolamine was added under the action of hydrogen to produce the synthesis reaction of Eltrombopag (IX); The 3′-amino-2′ hydroxybiphenyl-3-formic acid and 2-(3,4-dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazole- 3-one(VII) in step (3), reacted in a mixed solution of sodium nitrate and sodium bicarbonate.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-(3,4-Dimethylphenyl)-3-methyl-1H-pyrazol-5(4H)-one, and friends who are interested can also refer to it.