Electric Literature of 26621-44-3, A common heterocyclic compound, 26621-44-3, name is 3-Nitro-1H-pyrazole, molecular formula is C3H3N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Under inert gas (eg high purity nitrogen) protection to 10 mlSchlek reaction tube was added 0.02 mmol of water-soluble palladium on water-bound monophosphine salt compound (18), 1.0 mmol of 4-methoxy-2-chloropyridine, 1.5 mmol of 3-nitropyrazole, 3 mmol of potassium carbonate and 5 ml of Water, the reaction tube was replaced with nitrogen three times, and then heated to 100 C with an oil bath under magnetic stirring, and the reaction was refluxed for 24 hours. The oil bath was removed and the reaction was concentrated with a rotary evaporator. The residue was chromatographed on silica gel using ethyl acetate as the developing solvent to give pure product 4-methoxy-2-pyridine-3-nitroPyrazole in 85% yield.
The synthetic route of 26621-44-3 has been constantly updated, and we look forward to future research findings.