Synthetic Route of 20154-03-4, These common heterocyclic compound, 20154-03-4, name is 3-(Trifluoromethyl)-1H-pyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a stirred solution of 10 g (73.5 mmol) 3 -(trifluoromethyl)- 1H- pyrazole (3) in DMSO (150 ml) were added 9.9 g of potassium tert.-butoxide portion wise. After stirring for 5 minutes drop wise addition of 12 ml of iodoethane followed by stirring overnight were conducted. Water was added afterwards and the pH value was adjusted to 3 by using IN HC1. The mixture was diluted with MTBE and extracted two more times with MTBE. The combined organic phase was washed with Na2S203-solution, water and brine yielding 8 g (67 percent) of the ionic liquid 8.
The synthetic route of 20154-03-4 has been constantly updated, and we look forward to future research findings.